M7 Challenges Local Scientists To Fast-Track HIV-AIDS Vaccine Development As He Commissions Bone Marrow Transplant.

 

President Yoweri Kaguta Museveni has challenged local scientists to fast- track the development of the HIV/AIDS vaccine.“It's good that you are waking up, and we must get the vaccine,” he said.

The President made the remarks today as the Chief Guest during the

Joint Clinical Research Center (JCRC) 30th Anniversary celebrations held at the center's headquarters in Lubowa, along Entebbe Road, Wakiso District. President Museveni underscored the role of vaccines in solving problems such as epidemics.

“I'm surprised that you have taken so long to get a vaccine because

during the AIDS Conference in Florence Italy, I don't remember which year it was, there was quite a bit of optimism that we would get the vaccine even me I was almost becoming like a Molecular Biologist; I was following very closely because that time we were saying that the problem with this AIDS virus is that it mutates but then people were saying that although its mutating, some portions of it don't change and if we can capture those, then we could get a common denominator in the variants of the virus and recognise it.

Then later alone I heard that no, this virus is very dangerous because it enters your defence system and that is why it is not detectable. Now what are we doing about this enemy? What happened to that theory of the common denominator in spite of the mutations?” he inquired. “You know how much these vaccines can solve problems. In the other century, we had a very bad problem with smallpox, it killed a lot of people in 1893 but when the vaccine was introduced, it disappeared. I don't think that smallpox still exists now. Therefore, I challenge the scientists especially our own scientists to wake up and deal with these problems instead of just sitting and waiting for others to the work.” At the same event, President Museveni commissioned the first ever bone marrow transplant center at JCRC headquarters. He also laid a foundation stone and signed off a master plan of the new proposed cell and gene therapy center.

“I congratulate JCRC for the bone marrow transplant center which you have just opened here. As Prof. Ibingira said, when it's done here, it will be much cheaper than when you do it outside,” he stated. President Museveni however revealed that he is trying to persuade some religious people that it is not true that when you do biotechnology and gene therapy, you are interfering with the work of God.

“We have been doing it for a long time. I have been a genetic engineer for a long time because we the cattle keepers always select the good breeders which will produce more milk, there are some bulls which produce only females, we the cattle keepers are the people who appreciate females more than anybody else. If your cows are producing mainly male bulls, then you are very unlucky because what do you do with the bulls? But if they are producing females, they are good because you have a bigger breeding population,” President Museveni stressed.

“So, I want to convince my religious people that we have been doing that because of the performance criteria of those bulls. We are doing

engineering but using the slow way of aggregating these genes. Now

these scientists, because they have the whole chain of genes, they can know which one is causing problems and deal with it, just like we are doing it in breeding. We can also do it using this laboratory based method. It is not a new practice,” he added. A bone marrow transplant is a procedure that infuses healthy blood- forming stem cells into your body to replace bone marrow that's not producing enough healthy blood cells. A bone marrow transplant is also called a stem cell transplant whereas gene therapy involves altering the genes inside one’s body’s cells in an effort to treat or stop disease.

The President also hailed the partners who have worked closely with

JCRC in promoting research and clinical development over the years. “I specifically want to thank Dr. Manfred Dietrich; we should recognize his contribution with a medal or something for the tremendous contribution towards this center. I also thank our other partners like the United States Agency for International Development (USAID), United States President’s Emergency Plan for AIDS Relief (PEPFAR), Centers for Disease Control and Prevention (CDC), and all other groups. We thank them so much for their partnership, God will remember them and give them some place in heaven,” he said.

The President later awarded the former Prime Minister, Rt. Hon. Amama Mbabazi, the former Deputy Chief Justice of Uganda, His Lordship Steven Kavuma, Dr. Crispus Kiyonga, Justice Epelu Opio, Mr. Ben Luwum among others for their immense contribution towards JCRC. On the other hand, the Minister of Health, Dr. Jane Ruth Aceng thanked the President for spearheading the HIV/AIDS fight in Uganda and commitment to end AIDS by 2030. “We thank you for your continued support to the health sector and your

vision to have a healthy and productive population that contributes to

socio- economic growth and national development,” Dr. Aceng said.

“As we are all aware, the first case of HIV AIDS was identified in Uganda in 1982. Your Excellency, through your leadership, awareness and preventive messaging was conducted early as soon as the epidemic was identified and the Ministry of Health established its sentinel sites that were used to monitor the trend in the HIV/AIDS prevalence which reached a peak of 30 percent in Kampala by 1992 but with no available treatment,” she said.

“Allow me to appreciate you, Your Excellency, as many others have said for establishing this great institution- the Joint Clinical Research Centre which you started in 1992 aimed at finding a scientific solution to HIV/AIDS which was a major health problem to the Ugandan population.” The Minister also attributed the improvement in the HIV/AIDS statistics in Uganda to the use of a multi-sectoral approach in partnership with the country's development partners.

“The Joint Clinical Research Centre has made significant contributions on each step of the journey that we have taken towards the end of HIV/AIDS as a public health threat and we expect it to make a significantcontribution in the last mile of this journey in ending AIDS by 2030,” Dr. Aceng noted.

“As we move to the last frontier in the cure of HIV, JCRC is again at the forefront of efforts to find an effective HIV vaccine and to ensure that Ugandan scientists actively contribute to the designing of research for the HIV/AIDS cure especially through the emerging cell and gene therapy technologies whose clinical trials have already started in the United States of America,” she added. Prof. Charles Ibingira- Chairman Board of Directors of JCRC hailed the President for taking a bold decision to address the HIV challenge head- on at a time when his revolutionary leadership was required most because the disease was new, and many lives were lost at that time. “People were dying right and left , we had no hope, but because of your

vision, the situation changed. Your great vision to start JCRC to

intervene and address the desperate situation that the Ugandans were

in and the untold suffering with HIV/AIDS is a clear demonstration of your great leadership and care for Ugandans. We can never thank you enough for this,” he added.

The Executive Director of JCRC, Dr. Cissy Kityo highlighted that the center has played a vital role in the fight against the HIV/AIDS in the region by pioneering the use of HIV drugs in sub-Saharan Africa in 1992 and imported the first generic HIV drugs from India to bring down the costs and subsequently became the case study for the architecture of the PEPFAR. “Your Excellency, our researchers have worked and continue to work tirelessly to discover new insights, treatment and solutions to some of the most challenging issues facing our nation and region. JCRC has been part of groundbreaking research that has contributed to Global knowledge and informed change of policy and guidelines and the course

of the medicines we are taking,” Dr. Kityo said.

She added that the center is now leading the first study in Africa with

evaluating new HIV drugs which are given as injections every two

months instead of taking pills every day.

“We will continue to push the boundaries, there is no limit of knowledge

and strive for excellence in research. Our laboratory has pioneered

many tests to monitor how HIV drugs are working including CD4 count,

viral load and testing of children as early as 6 weeks, we used to test

until at 8 months, now we can test them using molecular tests and

determine if they should start treatment,” Dr. Kityo said.

In her conclusion, the Executive Director invited the President to present

an artistic impression of a house to one of the JCRC’s inpatient, Ms.

Josephine Nakandi who was diagnosed with HIV/AIDS at an age of

three and later developed meningitis which has completely affected her

brain.

“We have provided her with healthcare, put her in a school for the

disabled. She has been renting and the JCRC staff has contributed to

her monthly rent. As part of a corporate social responsibility, we have

managed to buil d for her a house at Kitende about 12 kilometres from

here, that is the artistic impression that we have here, please join us in

presenting it to her,” she requested President Museveni.

Meanwhile, the President also donated Shs100m to the JCRC SACCO

and also contributed Shs30m towards Ms. Nakandi.